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Paediatric
Formulating better medicines for children – 13th EuPFI Conference 2021 virtual
22.09. - 23.09.2021 | online platform, Germany
Dear Colleagues,
The EUPFI is delighted to announce its 13th annual (virtual) scientific conference and excited to bring you some of the interesting presentations and sessions you were looking forward to.
EuPFI (European Paediatric…
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Polymeric and Lipid Nanoparticles: Which Applications in Pediatrics?
This review aims to provide the state of the art on polymeric and lipid nanoparticles, used or suggested to approach pediatric diseases’ problems and needs, and to inspire new researches in this field. Several drugs are currently not available in formulations suitable for pediatric patients.…
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Application of mini ODTs and coin-shaped ODTs with high performance excipients for pediatric…
There is strong clinical need for pediatric formulations from healthcare professionals and caregivers since the number of available pediatric formulation is limited. Currently oral administration is the main route of administration for pediatric formulations in the market. For development of…
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Comparative taste-masking evaluation of microencapsulated bitter drugs using Smartseal 30D and…
The taste of drug substances plays a key role in the development of paediatric formulations with suitable organoleptic properties. The aim of the study was to evaluate the taste masking effectiveness of Smartseal 30D and ReadyMix on a range of bitter drug substances such as diphenhydramine HCl…
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The Development of Minitablets for a Pediatric Dosage Form for a Combination Therapy
Minitablets are an appealing option for an age-appropriate pediatric dosage form. In particular, for combination therapies where multiple active ingredients are dosed simultaneously, the use of minitablets will enable independent adjustments of each dose. The work presented describes the development…
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Evaluation of dissolution techniques for orally disintegrating mini-tablets
Mini-tablets are suitable for paediatric as well as geriatric use since they may provide flexible and accurate dosing and administration. Due to the minute tablet size, there is a need for new standardized quality evaluation procedures and conventional techniques may have to be adopted. The main…
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Skin penetration/permeation success determinants of nanocarriers: Pursuit of a perfect formulation
The advent of nanocarriers in the field of pharmaceutical drug delivery, while exhibiting considerable advantages, has created challenges for researchers. Among the applications of nanocarriers, drug delivery to the skin has attracted increasing attention in recent decades due to its advantages over…
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Drug solubilization during simulated pediatric gastro-intestinal digestion
To increase the understanding of how drugs behave following oral administration to the pediatric population, the aim of the present study was to investigate the solubilization of fluconazole and ibuprofen during simulated gastro-intestinal (GI) digestion, using an immediate transfer model mimicking…
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Evaluation and Comparison of Solid Lipid Nanoparticles (SLNs) and Nanostructured Lipid Carriers…
The aim of this study was the optimization of solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in terms of physicochemical and biopharmaceutical properties, to develop effective and stable aqueous liquid formulations of hydrochlorothiazide, suitable for paediatric therapy,…
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Excipients in the Paediatric Population: A Review
This theoretical study seeks to critically review the use of excipients in the paediatric population. This study is based on the rules and recommendations of European and American drug regulatory agencies. On the one hand, this review describes the most frequent excipients used in paediatric…
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