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Paediatric
Survey on typical dosing vehicles used to simplify the administration of pediatric medicines
On behalf of Prof. Dr. Sandra Klein University of Greifswald we gladly invite you to participate in this survey on typical dosing devices to administer pediatric medicines and with this support the development of "better medicines for children".
Dear colleagues, friends, health-care…
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High Acceptability of an Orally Dispersible Tablet Formulation by Children
There is a high unmet medical need for child-appropriate oral dosage forms. The acceptability of a novel placebo orally dispersible tablet formulation (pODT) was therefore evaluated. Monolithic tablets contain an inorganic calcium carbonate/calcium phosphate carrier material as the main excipient.…
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Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP…
Although oral drug delivery is the preferred administration route and has been used for centuries, modern drug discovery and development pipelines challenge conventional formulation approaches and highlight the insufficient mechanistic understanding of processes critical to oral drug absorption.…
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Patent landscape of paediatric-friendly oral dosage forms and administration devices
The current availability in dosage forms designed specifically for children is limited, constituting common practice the use of unlicensed or off-labeled medicines and extemporaneous preparations. Swallowing difficulties and taste aversion are the primary reasons for medicine rejection, therefore…
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ExciPerience 2021- The complete overview and explanation of the new event for pharmaceutical…
What is the ExciPerience?
ExciPerience 2021 was the new virtual event around every aspect of pharmaceutical excipients. ExciPerience covered all areas from basic or advanced research and formulation to manufacturing and regulatory. It was the intersection between all the different perspectives…
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Formulation and stability study of hydroxychloroquine sulfate oral suspensions
Hydroxychloroquine is an antimalarial drug indicated in the treatment of acute attacks of malaria due to Plasmodium vivax, P. malariae, P. ovale, and susceptible strains of P. falciparum. It is also used for the treatment of rheumatoid arthritis, discoid and systemic lupus erythematosus, and more…
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Best Practices for Selection of Excipients for Paediatrics – Workshop Reflection
The development of age appropriate formulations for the paediatric population has become one of the key areas of focus for the pharmaceutical industry – with a subsequent influence on excipient use. Selection of excipients with appropriate safety and tolerability is a major hurdle in paediatric…
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The evaluation of dynamic compaction analysis as a QbD tool for paediatric orodispersible mini…
The formulation of orodispersible minitablets (ODMTs) usually targets the disintegration time and mechanical strength, but should also consider a series of technological issues related to powder flow and compression behaviour. In this regard, the present study aimed to evaluate the contribution of…
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An Update on Pharmaceutical Strategies for Oral Delivery of Therapeutic Peptides and Proteins in…
While each route of therapeutic drug delivery has its own advantages and limitations, oral delivery is often favored because it offers convenient painless administration, sustained delivery, prolonged shelf life, and often lower manufacturing cost. Its limitations include mucus and epithelial cell…
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Study of drug particle distributions within mini-tablets using synchrotron X-ray microtomography and…
Uniform drug distribution within fast disintegrating tablets is a key quality measure to ensure a reliable, steady, and targeted release of the contained active pharmaceutical ingredients. In this work, the drug particle distribution in mini-tablets was studied with synchrotron phase contrast X-ray…
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