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Paediatric
3D printing of gummy drug formulations composed of gelatin and an HPMC-based hydrogel for pediatric…
The 3D printing of drug formulations is a promising method for preparing tailored medicines following the approval of 3D printed tablets by the US FDA in 2015. Appropriate dosage forms for pediatric patients are deficient because drugs have been developed for mainly adult patients.
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Development of High Drug Load Multiparticulate Beads Using an Extrusion-Spheronization Process
Purpose
Drug X is high solubility, high permeability BCS/DCS I small molecule drug.
High dose and potential pediatric indication required multiparticulate formulation with not less than 80% drug loading to achieve flexible and low quantity dosing with potential for modified release…
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I Spy with My Little Eye: A Paediatric Visual Preferences Survey of 3D Printed Tablets
3D printing (3DP) in the pharmaceutical field is a disruptive technology that allows the preparation of personalised medicines at the point of dispensing. The paediatric population presents a variety of pharmaceutical formulation challenges such as dose flexibility, patient compliance, taste masking…
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Multiparticulates Part 4a: Functional coating applications – The Basics
This is the 4th Webinar on Multiparticulates in our series of "Multiparticulates - Modern oral drug products for our society". In this webinar Norbert Pöllinger will inform you on the basics of functional coating applications.
Multiparticulates Multiparticulates such as micropellets, pellets,…
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Evaluation of dissolution techniques for orally disintegrating mini-tablets
Mini-tablets are suitable for paediatric as well as geriatric use since they may provide flexible and accurate dosing and administration. Due to the minute tablet size, there is a need for new standardized quality evaluation procedures and conventional techniques may have to be adopted. The main…
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Multiparticulates For Paediatric Oral Drug Delivery – Glatt Pharmaceutical Services
As the demand for pediatric dosage forms continues to increase across the industry, there can be formulation challenges for this patient population. Pediatric patients may require different dosage forms depending on age ranges, and patient compliance can be significantly impacted based on the size,…
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A Biopredictive In Vitro Approach for Assessing Compatibility of a Novel Pediatric Hydrocortisone…
The objective of the present work was to screen whether a novel pediatric hydrocortisone granule formulation can be co-administered with common food matrices and liquids.
Methods
Pediatric hydrocortisone granules were studied using a biopredictive in vitro approach. Experiments included an in…
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High-efficiency dry powder aerosol delivery to children: Review and application of new technologies
Highlights
Key aerosol and device technologies are presented that maximize delivery to pediatric airways:Nose-to-lung administration with sufficiently small particles.
Active positive-pressure DPIs
Patient interfaces that minimize turbulence and jet momentum effects.
Highly dispersible…
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Multiparticulates for paediatric oral drug delivery – a Glatt.Pharmaceutical Services Webinar
As the demand for pediatric dosage forms continues to increase across the industry, there can be formulation challenges for this patient population. Pediatric patients may require different dosage forms depending on age ranges, and patient compliance can be significantly impacted based on the size,…
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3D-Printing with precise layer-wise dose adjustments for paediatric use via pressure-assisted…
The establishment of 3D-printing as manufacturing process for oral solid dosage forms enables new options for the individualized medicine.
The aim of this work was to develop a novel drug-printing model using pressure-assisted microsyringe (PAM) technology, which allows the precise dispensing of…
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