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Paediatric
Age-Appropriate Solid Oral Formulations for Pediatric Applications with a Focus on Multiparticulates…
This paper presents the output of a workshop held at the 11th Annual Conference of EuPFI (European Paediatric Formulation Initiative), in September 2019 in Malmo, Sweden, on the development of multiparticulates and minitablets as pediatric formulations. The workshop focused on three specific facets…
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Sensory aspects of acceptability of bitter-flavoured 7.5 mm film-coated tablets in adults, preschool…
There is great interest in demonstrating acceptability of solid oral formulations in paediatric populations. This study investigated the acceptability of small, 7.5 mm, bitter-flavoured, coated tablets in healthy children and adults. A randomised, double-blind acceptability test was performed…
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XStraw®: Easy way of administering correctly dosed medication
XStraw® is the name of a new dosage form using a drinking straw. The straw is pre-filled with a drug and enables a more comfortable intake for children and patients having diffculty swallowing.
With XStraw®, the intake is based on a pre-portioned drinking straw. This method guarantees a…
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Electrospun Orodispersible Films of Isoniazid for Pediatric Tuberculosis Treatment
Child-appropriate dosage forms are critical in promoting adherence and effective pharmacotherapy in pediatric patients, especially those undergoing long-term treatment in low-resource settings. The present study aimed to develop orodispersible films (ODFs) for isoniazid administration to children…
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Rheological & Suspending Properties of Commonly Used Oral Suspending Vehicles
Little is documented about the rheology of commonly oral used suspending vehicles (which include everything from water through commercial suspending agents to semi-solid foods such as yoghurt which are often used in the administration of medicines to children). Following on from this, little is…
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Easy to Swallow “Instant” Jelly Formulations for Sustained Release Gliclazide Delivery
It is a challenge to safely administer sustained release medicines to patients with dysphagia. Sustained release tablets must not be crushed and multiparticulates with large particle sizes cause gritiness reducing patient acceptability. The aim of this study was to develop “instant” jellies as…
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Acceptability of an orodispersible film compared to syrup in neonates and infants: A randomized…
Objectives
Reliable pediatric pharmacotherapy in all age groups requires the availability of age-appropriate drug administration. Orodispersible films (ODF) are a promising pediatric oral dosage form. ODFs would meet relevant targets: one dosage form matching the full range of pediatric patients,…
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European Paediatric Formulation Initiative workshop report: Improving the administration of oral…
Accurate dosing of the right medicine to the right patient is a key element of safe and efficacious pharmacotherapy, yet prone to technical challenges and human error when dosing involves the administration of small volumes of liquid medicines. For this reason, the topic has gained increased…
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Multi-Methodological Quantitative Taste Assessment of Anti-Tuberculosis Drugs to Support the…
The unpalatability of antituberculosis drugs is often cited as a major cause of non-adherence in children, yet limited quantitative taste assessment data are available. The aim of this research was to quantify the bitterness of isoniazid, rifampicin, pyrazinamide, and ethambutol dihydrochloride…
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New treatment for adrenal insufficiency in children
Professor Richard Ross from the University of Sheffield explains in this video the problematics of children suffering from adrenal insufficiency and the new treatment developed with the partners in the TAIN project. It is the first successfully developed effective treatment option for the rare…
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