Paediatric

Pediatric population is a sensitive sector of the healthcare and pharmaceutical field with additional needs compared to the adult population. Extemporaneous formulations for children are generally prepared by manipulating adult formulations, but medication errors can result in suboptimal efficacy…
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Oral pediatric formulations are either ready-to-use or require manipulation, and multi-use or single-use. Strong encouragement for preservative-free pediatric formulations has resulted in fewer multi-use solutions or suspensions in favor of single-use solid oral dosage forms. This updated review…
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07. February 2017 INTRODUCTION: The pharmacokinetics of excipients in neonates differs from that of older children. In a recent pan--European survey, two thirds of neonates received at least one potentially harmful excipient, such as ethanol and benzoates. The content of sweeteners…
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16. January 2017 Introduction Palatability of liquid medicines is a recognised challenge within the paediatric population Acceptability: “The overall ability of the patient and its caregiver to use the medicine as intended” Patient needs must be met when medicines are…
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16. January 2017 INTRODUCTION Dissolution of oral dosage forms depends on the GI tract physiological conditions, and definition of the dissolution profile in conditions that reflect the in vivo GI environment can lead to accurate prediction of the in vivo performance (1).…
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03. January 2017 Abstract Efavirenz (EFV), a non-nucleoside reverse transcriptase inhibitor (NNRTI), is part of first-line therapy for the treatment of human immunodeficiency virus type 1 infection (HIV-1/AIDS). This drug shows relatively low oral absorption and bioavailability, as…
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24. August 2016 Pediatric Medicines Are Not Child’s Play! AAPS Blog Jennifer Walsh Since the introduction of pediatric regulations in the USA (Pediatric Research Equity Act and Best Pharmaceuticals for Children Act) and Europe, there has been a huge  increase in the number of…
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25. February 2016 The STEP stands for Safety and Toxicity of Excipients for Paediatrics. It is a user-designed resource developed by European Paediatric Formulation Initiative (EuPFI) and United States Paediatric Formulation Initiative (USPFI) in collaboration for storage and…
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10. February 2016 The STEP stands for Safety and Toxicity of Excipients for Paediatrics. The STEP database is a user-designed free resource that compiles the safety and toxicity information of excipients that is manually extracted from selected information sources. Three tier…
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