Browsing Category
Paediatric
Current State of Minitablet Product Design: A Review
Abstract
Interest in minitablets (MTs) has grown exponentially over the last 20 years and especially the last decade, as evidenced by the number of publications cited in Scopus and PubMed. MTs offer significant opportunities for personalized medicine, dose titration and flexible dosing, taste…
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The Past, Present, and Future of Oral Dosage Forms for Children
Abstract
The administration of medications to children has been a challenge for parents and caregivers for generations. Pharmaceutical companies have often overcome the difficulties of weight-based dosing and the inability of most young children to swallow solid dosage forms by creating oral…
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Potentially Harmful Excipients: State of the Art for Oral Liquid Forms Used in Neonatology and…
Abstract
The pediatric population exhibits an important age-dependent heterogeneity in pharmacokinetics and pharmacodynamics parameters, resulting in differences in drug efficacy and toxicity compared to the adult population, particularly for neonates. Toxicity and efficacy divergences have been…
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Palatability and Stability Studies to Optimize a Carvedilol Oral Liquid Formulation for Pediatric…
Abstract
Carvedilol (CARV) is a blocker of α- and β- adrenergic receptors, used as an “off-label” treatment for cardiovascular diseases in pediatrics. Currently, there is no marketed pediatric-appropriate CARV liquid formulation, so its development is necessary. Palatability (appreciation of smell,…
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3D Printing of Dietary Products for the Management of Inborn Errors of Intermediary Metabolism in…
Abstract
The incidence of Inborn Error of Intermediary Metabolism (IEiM) diseases may be low, yet collectively, they impact approximately 6–10% of the global population, primarily affecting children. Precise treatment doses and strict adherence to prescribed diet and pharmacological treatment…
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Pharmaceutical Formulations for Older Patients – Part 2
See the new book, edited by Mine Orlu, Fang Liu
Provides a better understanding on the EMA reflection paper on pharmaceutical development for older patients
Details reasons for applying advanced pharmaceutical technologies for the benefit of the ageing population
Discusses Advanced…
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Pharmaceutical Formulations for Older Patients – Part 1
See the new book, edited by Mine Orlu, Fang Liu
Provides a better understanding on the EMA reflection paper on pharmaceutical development for older patients
Details reasons for applying advanced pharmaceutical technologies for the benefit of the ageing population
Discusses Advanced…
Read More...
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Dispensing Oral Temozolomide in Children: Precision and Stability of a Novel and Ready to Use Liquid…
Abstract
Temozolomide (TMZ) is part of the therapeutic armamentarium used in managing pediatric cancers; however, available oral forms (capsules) are not adapted for use in children. Our aim was to assess the dose accuracy and stability of TMZ using capsule contents mixed with food compared with a…
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Desloratadine-Loaded Flexible Orally Dissolvable Tablets Made of Electrospun Fiber Mats
Patient compliance and personalized dose adjustments are important factors, especially in pediatric care. Orodispersible tablets (ODTs) are gaining importance as they increase patient compliance compared to other solid oral dosage forms. ODTs are solid dosage forms that disintegrate within seconds…
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A toolbox for mimicking gastrointestinal conditions in children: Design and evaluation of…
Abstract
The goal of the present work was to develop an in vitro toolbox to evaluate the oral administration of dosage forms to children of different age groups and under different administration conditions (fasted/fed). Based on current data on the gastrointestinal physiology of children, a set of…
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