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Paediatric
Buccal films: A review of therapeutic opportunities, formulations & relevant evaluation…
The potential of the mucoadhesive film technology is hard to ignore, owing to perceived superior patient acceptability versus buccal tablets, and significant therapeutic opportunities compared to conventional oral drug delivery systems, especially for those who suffer from dysphagia. In spite of…
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Development of a High-Dose Infant Air-Jet Dry Powder Inhaler (DPI) with Passive Cyclic Loading of…
Purpose
The objective of this study was to incorporate a passive cyclic loading strategy into the infant air-jet dry powder inhaler (DPI) in a manner that provides high efficiency aerosol lung delivery and is insensitive to powder mass loadings and the presence of downstream pulmonary mechanics.…
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Pioneering Taste Acceptability For All
Taste acceptability is an important factor in the development of a drug product, especially when it comes to paediatric dosage forms.
Gustoceutics provides a biosensor taste testing service to improve acceptability and compliance of medicines in the most vulnerable patient groups, particularly…
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Formulation and Development of Paediatric Orally Disintegrating Carbamazepine Tablets
Carbamazepine is a medicine used to manage epilepsy and partial or tonic-clonic seizures. This study aimed at formulating and obtaining carbamazepine orodispersible tablets for paediatric use at a 50 mg dose, with a diameter not greater than 6 mm and a tablet weight of 80 mg, through a direct…
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Development of a safe pediatric liquisolid self-nanoemulsifying system of triclabendazole for the…
Fascioliasis, a common parasitic infection observed in the pediatric patient population, is a leading cause of concern in countries with poor/unhealthy water resources. To treat this condition first line agent such as triclabendazole (TBZ) has been the choice therapy. However, there is a major…
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The Effect of Cellulose Nanofibers on the Manufacturing of Mini-Tablets by Direct Powder Compression
Mini-tablets (MTs) contain a small amount of active pharmaceutical ingredients in one small tablet. MTs are advantageous because they can be fine-tuned according to the age and weight of pediatric patients and they are easy for children and the elderly to swallow. However, there are manufacturing…
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Oral drug delivery strategies for development of poorly water soluble drugs in paediatric patient…
Selecting the appropriate formulation and solubility-enabling technology for poorly water soluble drugs is an essential element in the development of formulations for paediatric patients. Different methodologies and structured strategies are available to select a suitable approach and guide…
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Innovation in Paediatric Drug Delivery with miniMist®
What is miniMist®?
miniMist® is an inhalation device for children that makes inhalation of pharmaceuticals easy and highly effective using gold standard methods.
miniMist® uses break-through technology and delivers treatments in a way they have never been done before.
miniMist® can be…
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Innovations in Chewable Formulations: The Novelty and Applications of 3D Printing in Drug Product…
Since their introduction, chewable dosage forms have gained traction due to their ability to facilitate swallowing, especially in paediatric, geriatric and dysphagia patients. Their benefits stretch beyond human use to also include veterinary applications, improving administration and palatability…
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Development of a Child-Friendly Oral Drug Formulation Using Liposomal Multilamellar Vesicle…
Many medicines are only available in solid dosage forms suitable for adults, and extemporaneous compounding is required to prepare formulations for children. However, this common practice often results in inaccurate dosing and unpleasant taste, reducing the medication adherence. Here, we report the…
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