Pioneering Taste Acceptability For All

Taste acceptability is an important factor in the development of a drug product, especially when it comes to paediatric dosage forms.

Gustoceutics provides a biosensor taste testing service to improve acceptability and compliance of medicines in the most vulnerable patient groups, particularly children and the elderly. Based at UCL School of Pharmacy, Professor Duncan Craig and Dr Hend Abdelhakim have worked together for a number of years developing and testing paediatric dosage forms, including in-vitro taste assessment studies of raw pharmaceutical entities as well as formulated dosage forms. The work they have undertaken has assisted companies to move forward with their medicine design and optimization, based on a rapid, quantitative assessment of both drug and formulation taste assessment.

Why Gustoceutics?

Based at UCL School of Pharmacy, Professor Duncan Craig and Dr Hend Abdelhakim have worked together for a number of years developing and testing paediatric dosage forms, including in-vitro taste assessment studies of raw pharmaceutical entities as well as formulated dosage forms. The work they have undertaken has assisted companies to move forward with their medicine design and optimisation, based on a rapid, quantitative assessment of both drug and formulation taste assessment.

Services

Gustoceutics currently uses an electronic tasting system or ‘E-tongue’ (TS-5000Z) for taste-assessment of drugs and formulations, providing the clients with comprehensive statistical analysis and benchmarking against known bitter drugs. Using this information, we assign the drug a bitterness threshold that can be used to estimate the aversiveness expected from the clinical dose planned. We work with clients to optimise drug taste-masking by giving a breakdown for the taste profile of the samples as well as offering formulation strategies. As well as assessing the taste of drugs, we help clients understand the effects of the excipients added on the overall taste profile of the medicine. Once formulated, we use our expertise to help clients de-select formulations and make informed decisions about progressing formulation candidates. In addition, we can advise on age-appropriate dosage forms especially with regards to ease of swallowing and handling in various age groups.

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