This poster was presented at the 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical  (PBP) Technology, 18 - 21 March 2024, Vienna, Austria: INTRODUCTION Hot melt extrusion (HME) has become increasingly popular in…

The aim of this work was to study the possibility to use SepitrapTM as a carrier for the formulation of amorphous solid dispersions by HME (hot melt extrusion) processing aiming solubility enhancement of poorly water-soluble drugs.…

Porous hydroxyapatite (HAP) pellets were prepared by extrusion/spheronization/sintering and loaded with Lactobacillus (La-5). Micronized (PFm) or coarse size (PFc) microcrystalline cellulose were the pore formers, while HAP grades from…

Abstract Purpose Continuous wet granulation and drying require an adequate process control strategy to ensure the product quality. The most important critical quality attributes of dried granules are the granule size distribution and…

In this study, a concentration predicting soft sensor was achieved based on the Residence Time Distribution (RTD) of an integrated, three-step pharmaceutical formulation line. The RTD was investigated with color-based tracer experiments…

The present paper serves as a demonstration how an in-line PAT tool can be used for rapid and efficient process development in a fully continuous powder to granule line consisting of an interconnected twin-screw wet granulator, vibrational…

Comprehensive understanding of an integrated continuous pharmaceutical technology was achieved in this study by a combining design of experiments and mechanistic modeling-based simulations. The powder to granule line consisted of twin-screw…

As every Friday - find the top posts of the week! Top posts of the week #1 Chinese Excipient DMF #2 ZoomLab™ – The interview with Dr. Ferdinand Brandl from BASF #3 Development and Evaluation of Astaxanthin Orally Disintegrating Tablets…

In 2020 pharmaexcipients.com has shared over 800 articles so far which is about 3 posts per day. This shows how much topics are related with pharmaceutical excipients and how important they are for the drug product development and…