The molecular interactions between compound and polymeric carriers are expected to highly contribute to high drug load and good physical stability of solid dispersions. In this study, a series of amorphous solid dispersions (ASD) of…

Holistic QbD approach for hot-melt extrusion process design space evaluation: Linking materials science, experimentation and process modeling The aim of this work was to investigate the relationship between formulation material…

new family of cellulosic ether polymeric excipients has been recently engineered for fabrication of amorphous solid dispersions (ASDs) of active pharmaceutical ingredients (API) via hot-melt extrusion (HME). These hydroxypropyl methyl…

Dissolution of poorly water-soluble active pharmaceutical ingredients (APIs) in polymeric melts plays an important role in the manufacturing of solid dispersions and solid solutions. The understanding of the dissolution is essential for…

03. October 2017 Supersaturating drug delivery systems (SDDS), as solid dispersions (SDs), stand out among strategies to enhance bioavailability of poorly soluble drugs.…