Tefose® 63 is a physical mixture of three components: PEG-6 palmitostearate, ethylene glycol palmitostearate and PEG-32 palmitostearate. The exact quantity of each component has been carefully selected to obtain a self-emulsifying base.…

Solid lipid nanoparticles (SLNs) are being extensively exploited as topical ocular carrier systems to enhance the bioavailability of drugs. This study investigated the prospects of drug-loaded SLNs to increase the ocular permeation and…

Colloidal liquid-in-liquid nanodispersions such as micro- and nanoemulsions were developed, characterized and compared as potential carriers for the topical administration of ibuprofen. Both colloidal systems were based on water as the…

Apigenin (Apig) is used as a model drug due to its many beneficial bio-activities and therapeutic potentials. Nevertheless, its poor water solubility and low storage stability have limited its application feasibility on the pharmaceutical…

Background: Metronidazole (MTZ) is an anti-oxidant and anti-inflammatory agent with beneficial therapeutic properties. The hydrophilic nature of the molecule limits its penetration across the skin. Existing commercial formulations have…

Innovative formulations, including solid lipid nanoparticles (SLNs), have been sought to improve skin permeation of non-steroidal anti-inflammatory drugs (NSAIDs). The present study explores the use of SLNs, prepared using a…

Treatment of posterior uveitis via topical route is desirable but cannot be achieved by conventional drug delivery strategies. Therefore, the aim of this study is to develop a topical nanomicellar formulation of an immunosuppressant drug,…

Topical formulations can effectively deliver therapeutics to a targeted area, with the added benefits of convenient application and reduced risk of systemic side effects. Due to these advantages, it should come as no surprise that this area…

The systematic development of pharmaceutical products using quality tools is highly essential for attaining robust performance by minimizing variability. Design of experiment (DoE) is now considered as an indispensable tool in…

There are 3 main conditions for a drug to penetrate into the skin and reach the blood circulation: solubilization in the formulation partition out of the vehicle diffusion into the epidermis Transcutol® P offers several…