Abstract Twin-screw melt granulation (TSMG) relies on the dispersive and distributive mixing at the kneading zone for granule growth to happen highlighting the critical role played by the kneading elements in TSMG. Despite extensive…

The Application of Fillers and Binders in Solid Dosage Formulation Pharmaceutical excipients are frequently used as fillers and fillers/binders in the formulation of solid dosage forms. Fillers add volume and confer mechanical properties…

Benefiting from the experience and technology of decades, Lactalis was able to enter the excipients’ market with its pharmaceutical lactose products in the forth quarter of 2023. The Lactalpha range is composed of milled and sieved…

Discover our, Merck, new Parteck® LM Excipient System: This exceptional product offers excellent flow properties, ensuring reliable dosing in both batch and continuous processes. With its consistent dosing and robust, constant mixing times,…

Abstract Cyclic peptides can bind challenging disease targets with high affinity and specificity, offering enormous opportunities for addressing unmet medical needs. However, as with biological drugs, most cyclic peptides cannot be applied…

Kneading is a process that mixes powders with liquid to produce homogeneous wet powders, with the process of kneading significantly affecting the quality and productivity of the final product. However, most kneading operations are…

Microcrystalline Cellulose MICROCEL® Microcrystalline cellulose is used as a filler/binder as well as a fiber source in various oral dosage forms in both pharmaceutical and nutraceutical applications. Microcrystalline cellulose has a long…

Aim of the Study Due to the physico-chemical properties of cannabidiol (CBD), the vast majority of the marketed products containing CBD are oils. To provide greater convenience in dosing, the goal of this experiment was to make…

This manuscript presents a lean industrial workflow to establish an operating design space for a commercial scale fluid bed granulation and drying process. The workflow involves confirming the operating design space by demonstrating that…