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The treatment and management of tuberculosis using conventional drug delivery systems remain challenging due to the setbacks involved. The lengthy and costly treatment regime and patients' non-compliance have led to drug-resistant…

Self-emulsifying drug delivery systems (SEDDS) are a proven method for poorly soluble substances works by increasing the solubility and bioavailability. SEDDS and isotropic mixtures, are composed of oils, surfactants, and occasionally…

Purpose In this work, praziquantel (PZQ) was incorporated into self-emulsifying drug delivery system (SEDDS) formulations to demonstrate that the increased apparent solubility and dissolution rate enhance intestinal permeation. Methods…

Gastroretentive drug delivery systems (GRDDS) get retained in the stomach for a long time, thus facilitating the absorption of drugs in the upper gastrointestinal tract. However, drugs that are difficult to dissolve or unstable in an acidic…

Introduction Preparation of self-microemulsifying drug delivery systems (SMEDDS) is a promising delivery approach for drugs with poor aqueous solubility to enhance their dissolution properties and hence oral bioavailability. The objective…

Curcumin (CU) possesses diverse pharmacological activities while being relatively safe; nevertheless, its clinical application is limited due to its physico-chemical characteristics. This study aimed to synthesize cinnamic acid based…

Purpose Pramipexole (Prami) is renowned as one of the most widely used drugs in the treatment of Parkinson’s disease. This study aimed to prepare slow-release nanofibers of Prami to reduce (or control) the release rate of the drug from the…

Since the last few decades, the development of smart hydrogels, which can respond to stimuli and adapt their responses based on external cues from their environments, has become a thriving research frontier in the biomedical engineering…

Aim Evaluation of different polyhydroxy surfaces in SEDDS to overcome the limitations associated with conventional polyethylene glycol (PEG)-based SEDDS surfaces for intracellular drug delivery. Highlights Polyethylene…