See some Frequently Asked Questions and the corresponding answers for Cyclodextrins and KLEPTOSE®: What are ß-Cyclodextrins (ß-CDs)? β-Cyclodextrins (β-CDs) are cyclic oligosaccharides with a bucket-like structure having a hydrophobic…

Abstract Interest in minitablets (MTs) has grown exponentially over the last 20 years and especially the last decade, as evidenced by the number of publications cited in Scopus and PubMed. MTs offer significant opportunities for…

The field of oral drug delivery has witnessed significant advancements, with a focus on developing innovative formulations to address challenges associated with traditional dosage forms, especially for patients with difficulties in…

Despite major improvements brought about by the introduction of taste-masked formulations of 4-phenylbutyrate (PB), poor compliance remains a significant drawback to treatment for some pediatric and dysphagic patients with urea cycle…

Functional film coatings are a topic which considers many formulators. Therefore we gladly share this interesting overview by BIOGRUND. Definition of “Functional Film Coating”: A functional film coating has an influence on the drug…

Abstract Carvedilol (CARV) is a blocker of α- and β- adrenergic receptors, used as an “off-label” treatment for cardiovascular diseases in pediatrics. Currently, there is no marketed pediatric-appropriate CARV liquid formulation, so its…

Abstract Orodispersible films (ODFs) are thin, mechanically strong, and flexible polymeric films that are designed to dissolve or disintegrate rapidly in the oral cavity for local and/or systemic drug delivery. This review examines various…

Hot melt extrusion (HME) is a common unit operation. It is broadly applicable in the pharmaceutical industry and can be implemented in a continuous manufacturing line. However, the conventional way of active pharmaceutical ingredient (API)…

Abstract The performance of particle coating is essentially determined by the morphology and uniformity of coating shells, which significantly depend on particle circulation. In this study, the geometry of a Wurster fluidized bed is…