Standard models used for evaluating the absorption of nanoparticles like Caco-2 ignore the presence of vascular endothelium, which is a part of the intestinal multi-layered barrier structure. Therefore, a coculture between the Caco-2…

This study aimed to develop and characterize a spray-dried powder aerosol formulation of a commercially available surfactant formulation, Survanta® intratracheal suspension, using the excipient enhanced growth (EEG) approach. Survanta EEG…

Introduction Phytocannabinoids are chemical compounds found in the cannabis plant which have been increasingly used as  therapeutics in recent years . They have shown to aid in chronic pain management for several diseases such as…

In this study, the general processability of cannabidiol (CBD) in colloidal lipid carriers was investigated. Due to its many pharmacological effects, the pharmaceutical use of this poorly water-soluble drug is currently under intensive…

Non-lamellar liquid crystal (NLLC)-forming lipids have gained attention as a novel component because of their ability to self-assemble upon contact with body fluids. In this study, a novel NLLC-forming lipid, mono-O-(5, 9,…

By Rumiana Tenchov, Information Scientist, CAS Posted February 18, 2021 Lipid nanoparticles are a vital component of the new Pfizer/BioNTech and Moderna mRNA COVID-19 vaccines, playing a key role in protecting and transporting the mRNA…

The anionic phospholipids (PLs) phosphatidylserine (PS) and phosphatidylglycerol (PG) are endogenous phospholipids with anti-inflammatory and immunomodulatory activity. A potential clinical use requires well-defined systems and for several…

The present work aimed to develop an optimized liposomal formulation for enhancing the anti-viral activity of propolis against COVID-19. Docking studies were performed for certain components of Egyptian Propolis using Avigan,…

Story of the week ExciPerience Safe the date March 9 & 10, 2021 for the first virtual event by pharmaexcipients around excipients. More to come soon! Top 5 posts of the week #1 The use of natural phospholipids as pharmaceutical…

December 3rd, 2020 - Written by Natalia Sannikova, R&D Manager, Ascension Sciences Introduction Solubility of hydrophobic drugs such as cannabinoids can be greatly improved by liposome encapsulation. Lipid composition can be adjusted…