HIV/AIDS stands as a global burden, and vaginal microbicides constitute a promising strategy for topical pre-exposure prophylaxis. Preceding the development of a microbicide containing tenofovir disoproxil fumarate (TDF) and…

Topical formulations may be used to deliver active pharmaceutical ingredients (APIs) to or through the skin. These formulations typically possess a relatively soft, spreadable consistency and are often formulated as either water-in-oil or…

It is widely recognised that patient adherence to topical drugs is low because of the complexity or inconvenience of the treatment regimen1 (difficult self- application, number of applications, time consumption, etc.). This leads to poor…

The development of topical inserts for the prevention of sexually transmitted infections (STIs), particularly human immunodeficiency virus (HIV), represents a promising alternative to oral and parenteral pre-exposure prophylaxis (PrEP)…

Understand the three formulation rules, ie solubility, partition, diffusion, for safe skin penetration enhancement with Gattefossé solubilizers. See the full video here.

Azithromycin (AZI) eye drops containing sodium hyaluronate (SH) were developed to improve the bioavailability of AZI. Interaction between AZI and SH in the AZI-SH formulation was investigated by differential scanning calorimetry, X-ray…

Quercus Suber Bark from Quercus suber L. is a natural, renewable and biodegradable biomaterial with multifunctional proprieties. In this study, we used it as solid particles to stabilize a Pickering emulsion. The main goal was to produce an…

Onychomycosis affects about 15% of the population. This disease causes physical and psychosocial discomfort to infected patients. Topical treatment (creams, solutions, gels, colloidal carriers, and nail lacquers) is usually the most…

Pharmaceutical excipients are an important part of any formulation and still we do not know enough about them. We therefore aim to improve the general knowledge on pharmaceutical excipients and have launched "Excipient Basics" on…

Soluplus is a pharmaceutical excipient used primarily in the manufacture of solid dispersions. The polymer also exhibits interesting rheology in aqueous solution, increasing in viscosity as the solution is warmed. This material could have…