24. November 2017 To avoid frequent drug administration, PLGA-based monolithic filament-shaped implants were prepared. In this study, the effect of different formulation…
13. November 2017 Amorphous solid dispersions (SDs) are considered as one of the most effective strategies for the formulation of poorly water-soluble compounds. The active…
09. June 2017 Abstract The main objective of this novel study was to develop chlorpheniramine maleate orally disintegrating films (ODF) using hot-melt extrusion…
09. June 2017 Abstract The formation of molecularly dispersed amorphous solid dispersions by the hot-melt extrusion technique relies on the thermal and mechanical energy…
31. March 2017
The majority of today’s new chemical entities are poorly water-soluble. One widely used means of overcoming that problem is to develop solid dispersions by mixing at the molecular level the drug candidate…
29. March 2017 Abstract Newly developed active pharmaceutical ingredients (APIs) are often poorly soluble in water. As a result the bioavailability of the API in the…
Abstract
In the present study, we aimed to prepare a gastroretentive drug delivery system that would be both highly resistant to gastric emptying via multiple mechanisms and would also potentially induce in situ supersaturation.…
22. February 2017 Hot Melt Extrusion (HME) technology is a widely used for manufacturing process in the plastic and pharmaceutical industries and is an efficient and simple…
24. November 2016 Misuse and Abuse of Prescription Drugs Prescription pain relievers are safe and effective when used correctly for a medical condition and under a…
22. November 2016
Investigation of the processing window for Affinisol and Plasdone - S630 polymers during Hot-melt extrusion (for 3D printing by fused deposition modelling)
INTRODUCTION
In recent years, the use of 3D…