Emerging Technologies and Functionality of Polymeric Excipients in Drug Product Development Covers regulatory and manufacturing aspects of 3D printing in drug development Particular focus on hot melt extrusion and extruded filaments…

In this study, an amorphous solid dispersion containing the poorly water-soluble drug, bisacodyl, was prepared by hot-melt extrusion to enhance its therapeutic efficacy. First, the miscibility and interaction between the drug and polymer…

Among the various 3D printing techniques, FDM is the most studied in pharmaceutical research. However, it requires the fabrication of filaments with suitable mechanical properties using HME, which can be laborious and time-consuming. DPE…

Background and purpose: Physicochemical properties of an amorphous solid dispersion (ASD) comprising an experimental grade of hydroxypropyl methylcellulose acetate succinate (HPMCAS-MX) with lower glass transition temperature have been…

Hot-melt extrusion is a well-established tool in the pharmaceutical industry, mostly implemented to increase the solubility of poorly soluble drugs. A less frequent application of this technique is to obtain formulations with extended…

3D printing offers the possibility to prepare personalized tablets on demand, making it an intriguing technology for hospital pharmacies. For the implementation of 3D-printed tablets into the digital Closed Loop Medication Management…

Sustained local delivery of meloxicam by polymeric structures is desirable for preventing subacute inflammation and biofilm formation following tissue incision or injury. Our previous study demonstrated that meloxicam release from hot-melt…

Parteck® MXP Excipient The hot melt extrusion difference Poor solubility of APIs is a critical challenge in drug development. One formulation technique to increase solubility and, consequently, improve bioavailability of drugs is hot…

This work developed immediate-release hot melt extruded pellets containing the poorly aqueous soluble drug Indomethacin with five different screw configurations for oral application. Moreover, numerical simulation concerning residence time…

In situ gelling systems (ISGS) can prolong retention time and bioavailability of ophthalmic solutions. The complexity and cost of ISGS avert their industrial scale-up and clinical implementation. In this study, we demonstrate novel…