Abstract Over the past 10 years, the interest in intranasal drug delivery in pharmaceutical R&D has increased. This review article summarises information on intranasal administration for local and systemic delivery, as well as for CNS…

The therapeutic potential of cannabidiol (CBD) has been explored to treat several pathologies, including those in which pain is prevalent. However, the oral bioavailability of CBD is low owing to its high lipophilicity and extensive…

Chronic wounds are a significant and growing health problem, and clinical treatment is often a painful experience. A topical dosage form would be optimal to treat this pain. Poloxamer 407, a thermosensitive polymer that is a liquid at low…

The eyes are the window to the world and the key to communication, but they are vulnerable to multitudes of ailments. More serious than is thought, corneal infection by herpes simplex viruses (HSVs) is a prevalent yet silent cause of…

This review summarizes the research on phospholipids and their use for drug delivery related to the Phospholipid Research Center Heidelberg (PRC). The focus is on projects that have been approved by the PRC since 2017 and are currently…

The development of probiotic formulations has attracted great attention of researchers and industrial community. Their beneficial effects have been demonstrated in human health, and in buccal cavity including prevention of gingivitis,…

Parenteral drug delivery plays a very vital role in pharmacotherapy of various acute and critical illnesses. Injectables have been preferred formulations over oral and topicals especially in case where rapid effects of drugs are required or…

Providing texture and stability A short video to explain how Gattefossé all-in-one emulsifiers help simplify topical formulations and enable to obtain a wide range of sensorial textures Tefose® 63: widely used oil-in-water…

Purpose Delivering ophthalmic drugs to the target tissues in eye is challenging due to transport barriers. Rapid tear clearance of the drug instilled as eye drops to treat anterior segment diseases results in a low ocular permeability of…

Aim The high doses of oral tacrolimus (TAC) (1,2) necessary to prevent acute rejection (AR) after vascularized composite allotransplantation (VCA) are associated with systemic adverse effects. The skin is the most antigenic tissue in VCA…