Disadvantages of solvent-based coatings and why alternatives are needed The coating of active substances requires the suspension of the auxiliary substances in a solvent. This mixture is then applied to the active ingredient particles. If…

You wonder how to improve tablets swallowability and taste? Look at the poster describing solutions with HPMCAS (Shin-Etsu AQOAT®) and L-HPC from their originator, Shin-Etsu. Download the Poster as a pdf here: Taste Masking Coating of…

The application of hot melt coating (HMC) as an economic and solvent-free technology is restricted in pharmaceutical development, due to the instable solid-state of HMC excipients resulting in drug release instability. We have previously…

The purpose is to present the application of the acoustic levitation as a model system for a coating process with non-spherical and light particles in the fluidized bed reactor. An acoustic levitator has been used to track a pellet in a…

Many parameters must be considered before and during the pharmaceutical coating process. Sometimes it is necessary to adjust parameters to get the best possible result. The correct and precise choice of process parameters is crucial for a…

Purpose: Novel tablet coating approaches include the development of continuous coating technologies. This requires a high level of automation to assure the quality and safety of the final coated product. Despite automation of control…

Purpose: Polyvinyl alcohol (PVA) is a well-established polymer for film coating. PVA is a synthetic, bio-compatible and toxicologically well characterized polymer. It is frequently used in pre-mixed coating formulations. Fixed combinations…

The general aim of this paper is to study the coating strength of different composite powders with an experimental approach based on mixing energy descriptors derived from linear velocity at the end of paddles. The chosen system is Cellets…

Suspension of microparticles in an easy-to-swallow liquid is one approach to develop sustained-release formulations for children and patients with swallowing difficulties. However, to date production of sustained-release microparticles at…

Optical Coherence Tomography (OCT) is a promising technology for monitoring of pharmaceutical coating processes. However, the pharmaceutical development and manufacturing require a periodic validation of the sensor’s accuracy. For this…