As a complement to vaccines, small-molecule therapeutic agents are needed to treat or prevent infections by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and its variants, which cause COVID-19. Affinity selection–mass…

A promising approach to tackle the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) could be small interfering (si)RNAs. So far it is unclear, which viral replication steps can be efficiently inhibited with siRNAs. Here, we…

COVID-19 pandemic has resulted in an unprecedented global public health crisis. It is obvious that SARS-CoV-2 vaccine is needed to control the global COVID-19 public health crisis. Since obvious advantages including fast manufacturing…

The SARS-CoV-2 global pandemic has seen rapid spread, disease mobidities and death associated with substantive social, economic and societal impact. Treatments rely on re-purposed antivirals and immune modulatory agents focusing on…

Review article by Mariana C. Castells, M.D., Ph.D., and Elizabeth J. Phillips, M.D. in The NEW ENGLAND JOURNAL of  MEDICINE  To date, the development of mRNA vaccines for the prevention of infection with the severe acute respiratory…

Inorganic polyphosphate (polyP) is a morphogenetically active and metabolic energy-delivering physiological polymer that is released from blood platelets. Here, we show that polyP efficiently inhibits the binding of the envelope spike…

An international study involving the Institute of Nanotechnology of the Cnr has found that quercetin acts as a specific inhibitor for the virus responsible for Covid-19, showing a destabilizing effect on 3CLpro, one of the key proteins for…

Genes required for SARS-CoV-2 entry into human cells, ACE2 and FURIN, were employed as baits to build genomic-guided molecular maps of upstream regulatory elements, their expression and functions in the human body, and pathophysiologically…

Niclosamide (NCL) is an effective anthelmintic agent that has been shown to possess broad-spectrum antiviral activity, including against SARS-CoV-2. Due to its poor solubility in aqueous medium, however, the commercially available NCL…

Currently, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2, formerly known as 2019-nCoV, the causative pathogen of Coronavirus Disease 2019 (COVID-19)) has rapidly spread across China and around the world, causing an outbreak of…