In this work a recently developed in-line measurement technique for monitoring of coating thickness was applied to a spray-coating process in a three-dimensional prismatic spouted bed. The layer thickness was quantified with an optical…

Film coating of pharmaceutical dosage forms, such as tablets and pellets, can be used to tailor the drug release profile. With that regard, a uniform coating thickness of a single tablet (intra-tablet), all tablets (inter-tablet) and…

Optical coherence tomography (OCT) is a contact-free non-destructive high-resolution imaging technique based on low-coherence interferometry. This study investigates the application of spectral-domain OCT as an in-line quality control tool…

The paper presents a new in-line measurement technique for determining the coating thickness and uniformity of pharmaceutical pellets during film-coating in a fluid-bed apparatus. Non-destructive and contact-free process monitoring was…

Abstract Advanced manufacturing technologies such as continuous processing require fast information on the quality of intermediates and products. Process analytical technologies (PAT) to monitor many critical quality attributes (CQAs)…

Information on the penetration depth, pathways, metabolization, storage of vehicles, active pharmaceutical ingredients (APIs), and functional cosmetic ingredients (FCIs) of topically applied formulations or contaminants (substances) in skin…

Microneedles (MNs) are micron-sized needles, typically <2 mm in length, arranged either as an array or as single needle. These MNs offer a minimally invasive approach to ocular drug delivery due to their micron size (reducing tissue…

Abstract The performance of particle coating is essentially determined by the morphology and uniformity of coating shells, which significantly depend on particle circulation. In this study, the geometry of a Wurster fluidized bed is…

Current study reports the combined technique of microneedle array patches and thermoresponsive gels. Microneedles array patch mediated in situ skin depots were evaluated for sustain drug delivery using sodium alginate/Poly…