23. November 2017 Abstract Hecogenin acetate (HA) is an acetylated sapogenin that has shown potential antihyperalgesic activity, inhibiting descending pain and acting in…
15. November 2017 Abstract Poor water-solubility remains a typical property of drug candidates in pharmaceutical development pipelines today. Various processes have been…
01. October 2017 Vitamin E TPGS (TPGS) has both surfactant and P-glycoprotein(P-gp) inhibitory effects. While surfactants were previously found to cause solubility-permeability…
25. September 2017 ABSTRACT The objective of the present study was to prepare amorphous solid dispersion system simvastatin – hydroxypropylmethylcellulose (HPMC) to…
31. August 2017
Abstract
A design of experiment (DoE) approach was used to investigate the critical formulation and processing parameters in spray drying ternary amorphous solid dispersions (ASDs) of…
17. August 2017
AFFINISOL™ HPMC HME of varied viscosity was successfully processed with Itraconazole into homogenous amorphous solid dispersions. The use of two viscosity grades blended to a final target did not influence…
25. July 2017 Abstract Solubility challenge for a poorly water-soluble drug gets further intensified when it is weakly ionic because the most common solubility…
30. June 2017 Abstract: Administered by an oral route, Furosemide (FUR), a diuretic used in several edematous states and hypertension, presents bioavailability…
08. June 2017
Abstract
Nanoextrusion was used to produce extrudates of griseofulvin, a poorly water-soluble drug, with the objective of examining the impact of drug particle size and polymeric matrix type–size of the…
22. May 2017
Abstract
Herein, interfacial interactions of amorphous solid dispersion formed by nitrendipine (TDP) and two types of water-soluble polymers (polyvinyl pyrrolidone K30 (PVP) and polyethylene glycol…