ATTRIBUTES OF EXCIPIENTS FOR HIGH-RISK FORMULATIONS Excipients play an important role in parenteral formulations, which are high-risk given their route of administration. They protect, support, and enhance stability and bioavailability,…

Orodispersible films comprise a promising dosage form with a wide range of advantages compared to conventional formulations. The electrospinning process can significantly enhance the relevant characteristics of orodispersible films, e.g.,…

Olmesartan medoxomil (OLM) is a first-line antihypertensive drug with low oral bioavailability (28.6%). This study aimed to develop oleogel formulations to decrease OLM side effects and boost its therapeutic efficacy and bioavailability.…

Abstract Objective DCN is a chondro-protective agent which displays inadequate oral bioavailability along with gastrointestinal side effects. It is a choice of drug for treatment of osteoarthritis. Therefore, the objective of this study…

Messenger RNA (mRNA) lipid nanoparticles (LNPs) have emerged at the forefront during the COVID-19 vaccination campaign. Despite their tremendous success, mRNA vaccines currently require storage at deep freeze temperatures which complicates…

This manuscript systematically assesses three different glycerides (tripalmitin, glyceryl monostearate, and a blend of mono-, di- and triesters of palmitic and stearic acids (Geleol™)) as potential gelator structuring agents of medium-chain…

The emulsion-based topical semisolid dosage forms present a high degree of complexity due to their microstructures which is apparent from their compositions comprising at least two immiscible liquid phases, often times of high viscosity.…

Abstract Sufficient ocular bioavailability is often considered a challenge by the researchers, due to the complex structure of the eye and its protective physiological mechanisms. In addition, the low viscosity of the eye drops and the…