Several contributions in answering granulation challenges including the use of computer simulation and well thought out experimental analyses are being researched. Using a twin screw granulator (TSG) by design of experiments (DoE),…

Press Release New study: BENEO’s galenIQ™ proves suitable for powder feeding in continuous manufacturing Mannheim (Germany), March 2023 – A recently published comparative scientific study demonstrates that BENEO’s agglomerated…

Entrectinib is a novel potent anticancer drug with poor aqueous solubility. A supersaturable self-nanoemulsifying drug delivery system of entrectinib is developed using a super saturation promoter. The components of the isotropic mixture of…

The aim of this feasibility study was to investigate the possibility of producing industrial-scale relevant, robust, high drug-loaded (90.9%, w/w) 100 mg dose immediate-release tablets of isoniazid and simultaneously meet the biowaiver…

β-Cyclodextrin/ibuprofen inclusion complex was synthesized by freeze-drying method and characterized for phase solubility profiles, infrared spectra, thermal analysis, and X-ray powder diffractograms. The inclusion complex with HP-β-CD, as…

Accurate and reliable continuous feeding is essential for the continuous manufacturing of solid-dose pharmaceuticals to ensure the reproducible composition of the final product. Consistent feeding of cohesive powders is challenging and…

Dihydromyricetin (DHM) is an important natural flavonoid. However, most of DHM preparations have shown shortcomings such as low drug loading, poor drug stability, and/or large fluctuations in blood concentration. This study aimed to develop…

A statistical design of experiments for a rotary fluidized bed agglomeration process is performed to improve both the knowledge of the process and the influence of the process parameters. Agglomerates of a pharmaceutical formulation are…

Orodispersible films comprise a promising dosage form with a wide range of advantages compared to conventional formulations. The electrospinning process can significantly enhance the relevant characteristics of orodispersible films, e.g.,…