INTRODUCTION
Most new active pharmaceutical ingredients (APIs) exhibit a very low solubility in water, leading to an insufficient absorption in the gastrointestinal tract and thus poor bioavailability. Several…
ABSTRACT
The aim of the present investigation was to enhance the aqueous solubility and dissolution rate of a poorly soluble drug, efavirenz, by preparation of solid dispersions with tocopheryl polyethylene glycol succinate (TPGS)-1000, a…
Binary co-amorphous systems (CAMS) are a type of solid dispersion containing an active pharmaceutical ingredient (API) and small molecule excipients. The properties of these substances make them novel and a very demanding aspect of…
The present study evaluates the effect of kosmotropic inorganic salts in the disintegration time and the in vitro dissolution behavior of tablets containing polyvinylpyrrolidone (PVP)-based amorphous solid dispersions (ASDs). Specifically,…
In this study metronidazole drug was encapsulated by hydroxypropyl methylcellulose and polyvinylpyrrolidone polymers from solutions using nano spray drying technology. The influence of the process parameters and formulation variables were…
Poor aqueous solubility (<0.1 mg/mL) affects a significant number of drugs currently
on the market or under development. Several formulation strategies including salt formation,
particle size reduction, and solid dispersion approaches…
12. June 2016 Introduction: Amorphous solid dispersions are considered as one of the most powerful strategies to formulate poorly soluble drugs. They are made up of an…
22. July 2015 Effect of Mannitol on Nucleation and Crystal Growth of Amorphous Flavonoids: Implications on the Formation of Nanocrystalline Solid Dispersion - Abstract In…