Introduction: Tablets are still the most widely used dosage form for oral application due to their simple administration and relatively low manufacturing costs. One main disadvantage of tablets is the difficulty in swallowing or chewing.…

Mini-tablets are suitable for paediatric as well as geriatric use since they may provide flexible and accurate dosing and administration. Due to the minute tablet size, there is a need for new standardized quality evaluation procedures and…

The selection of appropriate functional co-processed excipient (CPE) is a crucial stage in orodispersible minitablets (ODMTs) development. This paper aimed to identify the most important morphological attributes influencing the flowability…

This study exposes the potential usefulness of a new co-processed excipient, composed of alginic acid and microcrystalline cellulose (Cop AA-MCC), for the preparation of immediate drug release tablets by direct compression. Evaluation of…

This theoretical study seeks to critically review the use of excipients in the paediatric population. This study is based on the rules and recommendations of European and American drug regulatory agencies. On the one hand, this review…

The U.S. Food and Drug Administration (FDA) emphasizes drug product development by Quality by Design (QbD). Critical material attributes (CMAs) are a QbD element that has an impact on pharmaceutical operations and product quality.…

There is a high unmet medical need for child-appropriate oral dosage forms. The acceptability of a novel placebo orally dispersible tablet formulation (pODT) was therefore evaluated. Monolithic tablets contain an inorganic calcium…

Tableting by direct compression (DC) is one of the simplest and most cost-effective drug manufacturing approaches. However, most active pharmaceutical ingredients (APIs) and excipients lack the compression and flow properties required to…

Co-processed excipients may enhance functionality and reduce drawbacks of traditional excipients for the manufacture of tablets on a commercial scale. The following study aimed to characterise a range of co-processed excipients that may…

This article aims to compare three commercially available co-processed excipients (CPEs), namely the F-Melts® type C,M and F1. All three CPEs were subjected to the evaluation of their physical properties and afterwards compacts were…