Abstract Colonic drug delivery can facilitate access to unique therapeutic targets and has the potential to enhance drug bioavailability whilst reducing off-target effects. Delivering drugs to the colon requires considered formulation…

The stability of a moisture-sensitive drug in tablet formulations depends particularly on the environment’s relative humidity (RH) and the products’ prior exposure to moisture. This study was designed to understand drug stability in…

Aim of this study was to develop a tablet formulation for targeted colonic drug release by implementing two control mechanisms: A pH-sensitive coating layer based on Eudragit® FS 30 D to prevent drug release in the upper gastrointestinal…

It is recognised that paediatric indications and age-appropriate formulations are required to ensure that paediatric populations receive appropriate pharmacotherapeutic treatment. The lack of information on dosing, efficacy and safety data…

Tablet disintegration is an important pre-requisite for drug dissolution and absorption. The disintegration test is typically conducted at 37 °C, but the intragastric temperature may vary due to meals or fever. This study investigated the…

Orally disintegrating tablets are an emerging trend in novel drug delivery system and have received ever increasing demand during the last few decades. Orally disintegrating tablets ODTs are the dosage form which will disintegrate in mouth…

Mesenchymal Stem Cell (MSC)-derived Exosomes Trehalose SG MSC-derived exosomes are attracting attention for their application in regenerative medicine, drug delivery, diagnostics and cosmetics, and the need for a stable…

Understanding the tabletability change of materials after granulation is critical for the formulation and process design in tablet development. In this paper, a material library consisting of 30 pharmaceutical materials was used to…

Hayashibara ― A world leading supplier of pharmaceutical grade Trehalose SG Founded as a starch syrup manufacturer in 1883, Hayashibara has grown into a company with strong research and development expertise, engaging in original and…

The time taken by the tablet to break down into fragments or granules is called disintegration. The time it takes for a batch of tablets to dissolve into particles under certain circumstances is called a disintegration test. It essentially…