Co-processed dry binders for ODTs are important multifunctional excipients for tablet manufacturing by direct compression. Testing their binary mixtures with lubricants is an important aspect of their use in combination with drugs. The aim…

Register now for the new & free webinar from Fuji Chemical Industries!  27th September 2021 - 10:00 AM CEST Key discussions:  Neusilin behaviour Free flowing powder Acts as a glidant Neusilin acts as a binder under…

This study investigates the use of twin-screw binder-free melt granulation (BFMG) in the development of high-dose solid dose formulations for low melting point thermally stable drugs. Both ibuprofen and guaifenesin are examined. By…

Dose dumping is the major drawback of sustained release (SR) matrices. The current research aimed to develop the stable lipid-based SR matrices of quetiapine fumarate (QTF) using GeleolTM (glyceryl monostearate; GMS) as the lipid matrix…

Binder jetting is an additive manufacturing technique that creates three-dimensional constructs from a powder feedstock. It is used by several industries, including pharmaceuticals. This additive approach to manufacture provides several…

In twin screw melt granulation, granules are produced by passing mixtures of drug substances and polymeric binders through twin screw extruder such that temperatures are maintained below melting point of drugs but above glass transition of…

Binders or “granulating agents” are a critical formulation component in tablets made by direct compression, as well as dry, wet, and melt granulation, ensuring appropriate plasticity, compactibility, and binding ability. In wet granulation,…

The use of polymeric nanocapsules as a binder system to produce fluidized bed granules with improved in vivo bioavailability has recently been reported. This study evaluated how the nanocapsules influence the growth behavior of the…

The binders povidone (Kollidon 30), copovidone (Kollidon VA64), hypromellose (Pharmacoat 606), and three types of hyprolose (HPC SSL‑SFP, HPC SSL, and HPC SL‑FP) were evaluated regarding their suitability in twin-screw wet granulation. Six…

The suitability of pharmaceutical binders for continuous twin-screw wet granulation was investigated as the pharmaceutical industry is undergoing a switch from batch to continuous manufacturing. Binder selection for twin-screw wet…