The efficacy of narrow therapeutic index (NTI) drugs is closely related to their plasma concentration-time profile. Particularly for these compounds interindividual variability of gastrointestinal (GI) parameters relevant to in vivo drug…

24. March 2016 The increasing demand for personalized medicine necessitates the production of easily customizable dosage forms. As the number of possible dosage forms may scale towards infinity, their uniqueness require a…

Abstract Breast cancer continues to pose a substantial global health challenge, emphasizing the critical need for the advancement of novel therapeutic approaches. Key players in the regulation of apoptosis, a fundamental process in cell…

Palbociclib (PAL) is an anti-cancer molecule that is highly selective for CDK4/6 inhibition and approved for the management of advanced breast cancer. Due to its down-and-out aqueous solubility and poor oral bioavailability, therapeutic…

Abstract The amount of glidant and lubricant in a tablet formulation is driven by their primary functionalities of enhancing flowability and reducing particle-wall friction. However, their interaction can lead to undesirable outcomes. This…

Abstract BARETab® PH is a multi-functional ready to use premixed, co-processed ingredient for direct compression (DC) formulations. It is a combination of selective, largely used excipients for DC. Direct compression is the most widely…

Hydrochlorothiazide (HTZ) and Valsartan (VAL) are poorly soluble drugs in BCS classes IV and II. This study aimed to develop a method to assess the dissolution profile of tablets containing HTZ (12.5 mg) and VAL (160 mg) as a fixed-dose…

Reactive Oxygen Species (ROS) have attracted significant attention among researchers as they play a role in cell death when produced excessively. To address this issue, scientists are actively seeking suitable antioxidants that can…

An approach to differentially modify the internal surface of porous silicon nanoparticles (pSiNPs) with hydrophobic dodecene and the external surface with antifouling poly-N-(2-hydroxypropyl) acrylamide (polyHPAm) as well as a…