Abstract In this work, concentration prediction models applicable to a very wide range of concentrations for personalized tablet manufacturing were developed using near-infrared (NIR) spectroscopy. Tablet manufacturing experiments were…

In this work, the performance of two fast chemical imaging techniques, Raman and near-infrared (NIR) imaging is compared by utilizing these methods to predict the rate of drug release from sustained-release tablets. Sustained release is…

Abstract The moisture content of pharmaceutical powder is a key parameter contributing to tablet sticking during the tableting process. This study investigates powder moisture behavior during the compaction phase of the tableting process.…

In scope of achieving real-time release of tablets, quality attributes need to be monitored and controlled through Process Analytical Technology tools such as near-infrared spectroscopy (NIRS). The authors evaluated the suitability of…

High shear wet granulation and tableting (HSWG-T) are complex pharmaceutical processes, which makes tablet quality be influenced by many variables including raw material attributes, process variables, and intermediate granule properties. To…

As the pharmaceutical industry increasingly adopts the Pharma 4.0. concept, there is a growing need to effectively predict the product quality based on manufacturing or in-process data. Although artificial neural networks (ANNs) have…

Slow drug release, low drug-polymer miscibility, poor printability of polymers used, and high processing temperature are major challenges in developing FDM 3D-printed tablets. These challenges were addressed in this investigation by having…

Abstract Continuous Manufacturing Technology continues to gain importance in pharmaceutical manufacturing. Although traditional processes like direct compression, roller compaction, or wet granulation are used within the continuous…

This research demonstrates the use of fused deposition modeling (FDM) 3D printing to control the delivery of multiple drugs containing bioactive self-nano emulsifying drug-delivery systems (SNEDDSs). Around two-thirds of the new chemical…

The new CUB-20 inspection machine from Pharma Technology was launched in April 2021 and provides comprehensive, non-destructive prediction of the API fraction in tablets. Combining innovative Laser Scanner with NIR multipoint technology and…