Silica nanoparticles have entered clinical trials for a variety of biomedical applications, including oral drug delivery, diagnostics, plasmonic resonance and photothermal ablation therapy. Preliminary results indicate the safety,…

Phospholipids (PLs) are essential building blocks of all biological membranes exhibiting a huge variety of functions. They play an essential role in the natural digestive process of food and are excreted as component of bile by the liver.…

Zein is an FDA-approved maize protein featured by its manipulative surface and the possibility of fabrication into nanomaterials. Although extensive research has been carried out in zein-based technology, limited work is available for the…

The immediate release of chemotherapeutics at the target site, along with no premature release in circulation is always challenging. The purpose of this study was to develop a stimuli responsive drug delivery system, composed of lipid…

The Center for Drug Evaluation and Research (CDER) has launched the voluntary Novel Excipient Review Pilot Program (Pilot Program), which is intended to allow excipient manufacturers to obtain FDA review of certain novel excipients prior to…

Pediatric, geriatric, and other patients who suffer from swallowing difficulties represent a special patient group, where an increased need in appropriate formulation development is required. To overcome these mostly swallowability linked…

Highlights • Bedaquiline-loaded cubosomes (BQLC) displayed excellent particle size, zeta potential, and aerosolization behavior suitable for NSCLC treatment. • BQLCs were efficiently internalized by lung cancer cells and decreased…

Continuous manufacturing (CM) is defined as a process in which the input material(s) are continuously fed into and transformed, and the processed output materials are continuously removed from the system. Continuous manufacturing can be…