Amorphous solid dispersion (ASD) has become an attractive strategy to enhance solubility and bioavailability of poorly water-soluble drugs. To facilitate oral administration, ASDs are commonly incorporated into tablets. Disintegration and…

The concepts of mucoadhesion and mucoadhesive polymers were introduced in the 20th century, leading to several advantages. These included enhanced drug absorption and extended residence at specific site of action. Polymeric excipients…

PURPOSE Poor aqueous solubility is a significant issue in the current pharmaceutical industry with approximately 90% of new chemical entities in the development pipeline characterised as poorly watersoluble. Amongst various means to…

Drug delivery through the mucosal membranes has been exploited to overcome the disadvantages associated with more popular routes such as oral and intravenous. Rectal drug delivery, by virtue of high permeability, direct access to…

Rafoxanide (RAF) is a poorly water-soluble drug that forms a complex with povidone K25 (PVP) in a cosolvent system containing acetone and an alkaline aqueous medium. This study aims to investigate the impact of RAF-PVP complexation on in…

Parenteral drug delivery plays a very vital role in pharmacotherapy of various acute and critical illnesses. Injectables have been preferred formulations over oral and topicals especially in case where rapid effects of drugs are required or…

In recent years, mucoadhesive dosage forms due to their advantages have attracted the interest of researchers and developers. Polymeric excipients are included into the drug composition to give adhesion to the mucous membrane. AIM: The…

Colon-targeted drug delivery possesses numerous advantages in pharmaceutical delivery systems. Both local and systemic deliveries of active ingredients are possible with help of polymers in colon-targeted delivery. Targeting colon can be…

Peyer’s Patches (PPs) consist of transmucosal clusters of lymphoid follicles overlaid with a specialized lymphoepithelium and play an essential role in the initiation of mucosal immune responses in the gut. Regardless of extensive…

Polymeric inserts containing azithromycin-loaded Eudragit® L100 nanoparticles were developed to sustain the drug release and enhance its ocular performance. The solvent diffusion technique was employed to prepare nanoparticles. The…