Solid dispersion is one of the most effective ways to improve the dissolution of insoluble drugs. When the carrier can highly disperse the drug, it will increase the wettability of the drug and reduce the surface tension, thus improving the…

Artificial intelligence (AI) has the potential to reshape pharmaceutical formulation development through its ability to analyze and continuously monitor large datasets. Fused deposition modeling (FDM) 3-dimensional printing (3DP) has made…

In September we have shared 43 posts with our network. Check the top ranking of this week. Some changes in the top pages of the month and top posts of the year. Top posts of the week #1 DiCOM-DC, a co-processed excipient for direct…

Poor aqueous solubility of terpenophenolic compound Cannabidiol (CBD) is a major issue in the widespread use of this promising therapeutic polyphenol. Moreover, choosing the appropriate strategy to overcome this challenge is time-consuming…

ZoomLab™ is the Virtual Pharma Assistant from BASF.  Pharma Excipients had the chance to interview one of the "masterminds" behind ZoomLab™, Dr. Ferdinand Brandl. Ferdinand answered all our questions on ZoomLab™. See the video of the…

The overall aim of the thesis was to introduce new analytical techniques to characterize solid dispersion formulations. Solid dispersion formulations are employed to enhance the dissolution behavior and apparent solubility of poorly soluble…

The main objectives of this work were to develop and characterize new 3D printing filaments and print them directly onto a packaging material. Different blends of polymers were tested to achieve low-temperature printing filaments, which are…

Ubrelvy™ December 2019 and Koselugro™ April 2020 are the most recent FDA approval of drug using Vitamin E TPGS in the formulation. TPGS properties: Emulsifier - solubilizer of poorly soluble drugs - absorption enhancer - PgP inhibitor -…

Highlights • Solubility enhancement of Apremilast using Hot melt extrusion technology via Corotating Twin Screw Extruder. • Theoretical and experimental determination of drug-polymer miscibility. • Influence of Extruder…

This paper presents a rational workflow for developing enabling formulations, such as amorphous solid dispersions, via hot-melt extrusion in less than a year. First, our approach to an integrated product and process development framework is…