Continuous manufacturing in the pharmaceutical industry has been gaining traction in the past few years. To fully understand and optimise continuous manufacturing processes it is important not only to focus on the single units which act as…

Hot Melt Extrusion is a well established technology used in ASDs. Besides the advantage of being a solvent free method some attributes of the API and polymer have to be considered like glass transition temperature and decomposition…

The current study evaluated the effect of location and amount of various superdisintegrants on the properties of tablets made by twin-screw melt granulation (TSMG). Sodium-croscarmellose (CCS), crospovidone (CPV), and sodium starch…

The oral bioavailability of curcumin is limited, attributed to its low solubility or dissolution and poor absorption. Herein, the study describes formulation of curcumin-loaded mixed micelles of Gelucire® 48/16 and TPGS for its dissolution…

Desmopressin acetate (DDAVP) is an oligopeptide indicated for the treatment of primary nocturnal enuresis, for example. The poor oral bioavailability of DDAVP accelerated a shift to alternative routes of administration like nasal and…

It is key to understand powder blend characteristics in relation to tablet characteristics when using pharmaceutical 3D printing, in order to obtain 3D powder bed printed tablets that comply with the pharmaceutical specifications. There is…

The usage of plant origin natural gum polysaccharides in various biomedical applications is steadily rising in recent years because of their peculiar properties like biocompatibility, biodegradability, cytocompatibility and with no…

Purpose Proper taste-masking formulation design is a critical issue for instant-dissolving tablets (IDTs). The purpose of this study is to use the electronic tongue to design the additives of the 3D printed IDTs to improve…

Dissertation by Ilias El Aita: Part 2 The term 3DP is an umbrella term encompassing several technologies, which differ in the printing style and/or used material. Nevertheless, these technologies have the same starting point in common as…