Voriconazole (VRC), a second generation triazole derivative emerged as a promising candidate for the treatment of fungal infections. Voriconazole is commercially available as oral and intravenous formulations, however administration through…

In the present study, luteolin (LT)-loaded nanosized vesicles (LT-NVs) were prepared by a solvent evaporation–hydration method using phospholipid and edge activator. The formulation was optimized using three factors at a three-level…

An oral colon delivery platform based on a novel combination strategy, leveraging multiple physiological characteristics of the intestine, is proposed. The system comprises a drug core, a water-swellable/soluble inner layer based on a…

Poorly water-soluble drugs pose a significant challenge to developability due to poor oral absorption leading to poor bioavailability. Several approaches exist that improve the oral absorption of such compounds by enhancing the aqueous…

Fuji Chemical Industries specializes in producing porous spray-dried excipients for the pharmaceutical and nutraceutical markets. They spray-dry their excipients to produce free-flowing granules and unique internal structures that enhance…

The development of new parenteral biologics with high-vol­ume, high-viscosity formulations (> 1 mL, >15 cP) is triggering the need for devices that can deliver these therapies with the ease, safety, and low injection time required for…

Objective: Development of a technology for production of a stable injectable dosage form (IDF) of indolocarbazole derivative LHS-1269. Methods: LHS-1269 is an active pharmaceutical ingredient that was synthesized in the N.N. Blokhin…

Looking to enhance the solubility of poorly soluble drugs? Consider AFFINISOL™, a water-soluble polymer that optimizes solubility enhancement by maintaining stable solid dispersions and inhibiting API crystallization. It’s been…

INSTACOATTM 4G is a ready-mixed powder that can be rapidly reconstituted in water, for the film coating of solid oral dosage forms. It contains polymer, plasticizer, pigments, etc. in optimal ratios to achieve significant benefits in terms…

In this video Pharma Drama looks at the basic definition of an amorphous material - how they are defined, why they should really be considered as viscous liquids, and why they have different physical properties from crystalline materials.…