An oral colon delivery platform based on a novel combination strategy, leveraging multiple physiological characteristics of the intestine, is proposed. The system comprises a drug core, a water-swellable/soluble inner layer based on a…

The aim of this study was to examine the impact of solvents during the wet stirred media milling of cross-linked biopolymers considering breakage kinetics, physical stability of the suspensions, and microhydrodynamics. To this end, a model…

Due to the complexity and fragility of biological drug products, several challenges exist in their formulation development. Excipients are added to increase product stability, maintain tonicity, and facilitate drug delivery. The potential…

A variety of dosage forms have been developed in order to achieve effective and safe drug delivery in topical or systemic drug administrations. In this review, formulation research and process issues related to a popular oral dosage form,…

Pharmatrans Sanaq has added SANAQ® SP 205/206 to its DiCom range of Co-Processed Excipients supporting Direct Compression (DC) applications. DiCom SANAQ®  SP205 and SP206 are both based on microcrystalline cellulose (MCC), co-processed…

Phytochemicals are increasingly found in many food, chemical and agricultural items. Product and process optimization is becoming ever-more important in all of these industries, with a focus on quality, manufacturing efficiency, stability…

At present, the risk of generic substitutions in warfarin tablets is still being discussed. The aim of this study was to assess whether API interactions with commonly used excipients may affect the safety of generic replacement of warfarin…

Purpose Producing several controlled- release 3D printed tablets from polymer blends with the required target product profile has been a challenge. Thus, experimental design could be applied to rationally explore the impact of the…