The inhibitory and bactericidal capacity of Listex P100 bacteriophage has been studied against different concentrations of Listeria monocytogenes in stationary and exponential phases. Three different matrices were employed to developed…

Topical formulations can effectively deliver therapeutics to a targeted area, with the added benefits of convenient application and reduced risk of systemic side effects. Due to these advantages, it should come as no surprise that this area…

Preparing a suitable formulation for parenteral administration is already a difficult task; this, coupled with poor water-soluble new chemical entity (NCE), complicates this situation even further. There are several methodologies available…

Pharmaceutical excipient development is an extensive process requiring a series of pre-formulation studies to evaluate their performance. The present study compares the conventional compaction and compression pre-formulation studies with…

Lipids are gaining enhanced momentum due to their vital role in the field of RNA therapeutics and vaccine development for diseases such as cancer and COVID-19. Currently, there are 18 liposomal drugs approved by the U.S. Food and Drug…

Bedaquiline fumarate (BDQN) is approved in year 2012 to treat multidrug resistance tuberculosis (MDR-TB) through accelerated approval pathway by FDA. It belongs to class II of biopharmaceutical classification system (BCS) and shows poor…

What's in a vaccine? With the emergence of COVID-19, the crucial role that vaccines play in protecting our health has come into sharp focus. During this pandemic hope comes in the form of a vaccine and immunologists around the world are…

The therapeutic potential of cannabidiol (CBD) has been explored to treat several pathologies, including those in which pain is prevalent. However, the oral bioavailability of CBD is low owing to its high lipophilicity and extensive…

Review article by Mariana C. Castells, M.D., Ph.D., and Elizabeth J. Phillips, M.D. in The NEW ENGLAND JOURNAL of  MEDICINE  To date, the development of mRNA vaccines for the prevention of infection with the severe acute respiratory…