Twin screw melt granulation is a new alternative method for granulation that offers several advantages over wet and dry granulation methods. Twin screw melt granulation has been rapidly gaining interest over recent years in the…

Melt granules of DI-CAFOS® A12 and 15% (w/w) Kolliphor® P407 were manufactured in a twin-screw granulator (TSG) at five different conditions (screw speed and throughput varied) and compared to granules manufactured in a high-shear…

In this study, a co-processed excipient (Cop AA-MCC) was prepared from alginic acid (AA) and microcrystalline cellulose (MCC101) using a laboratory scale high-shear granulator. The obtained granules were compared to the primary materials…

After a week without Friday's Top 5 we are back again. It seems that lipid excipients are very much of interest - check the post "Functionalization of lipid-based formulations for oral drug delivery of insulin" and "Gattefossé - lipid…

The challenge of developing wet granulation processes High shear mixers are traditionally the preferred choice for wet granulation. After initial blending of the dry components, a binder solution is added, whilst mixing continues, to wet…

We have done a series of webinars in the last months with our partners in the excipients area. They are very interesting with a lot of specialist knowledge included! See here the list of our most watched and important webinars. Also have…

Wet massing is commonly performed during the wet granulation process after the addition of a liquid binder. Torque values were measured using a Mixer Torque Rheometer (MTR) by the method of multiple additions of water and variable mixing…

Here is BIOGRUNDs step-by-step guide how to prepare a suspension. Please be aware that all parameters have to be adjust individually. Equipment & Material Equipment: propeller stirrer, beaker Material: Water, AquaPolish Here…

Considering microneedles (MNs) as transdermal drug delivery tools is driven by some crucial factors among which easy handling, simple administration and better patient compliance are primary. Achievable tailored microneedle production…

Coating of particles is a widely used technique in order to obtain the desired surface modification of the final product, e.g., specific color or taste. Especially in the pharmaceutical industry, rotor granulators are used to produce round,…