Webcast PharmTech.com In a continuous process, mono-functional excipients must be added through individual feeders, possibly resulting in multiple sources of variability. Alternatively, a single high-functionality co-processed excipient…

The manufacture of oral dosage form may induce changes in the physical form of an active pharmaceutical ingredient. Once such example includes formation of hydrate during granulation followed by the reverse transition to the anhydrous form…

irect compaction tableting, a desired manufacturing option, is infeasible for blends containing fine cohesive poorly-compactable APIs at higher drug loadings. In this study, the feasibility of using fine, dry coated excipients is…

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There has been a steady increase in the interest towards employing nanoliposomes as colloidal drug delivery systems, particularly in the last few years. Their biocompatibility nature along with the possibility of encapsulation of…

Objectives: We aimed to examine the administration of eight potentially harmful excipients of interest (EOI), including paraben, polysorbate 80, propylene glycol, benzoate, saccharin sodium, sorbitol, ethanol, and benzalkonium chloride, to…

The development of effective forms to incorporate poorly soluble drugs into delivery systems remains a problem. Thus, it is important to find alternatives such as finding excipients that increase drug solubility. Ionic liquids (ILs),…

Nasal application of powder formulations has garnered attention because of its significant potential for systemic drug delivery. Because a powder drug must first diffuse from the formulation and dissolve in the nasal cavity fluid before…

The mechanism of colloidal silica action to improve flow properties of pharmaceutical powders is known to be based on inter-particle force disruption by silica particles adhered to the particle surface. In the present article, the kinetic…