Spouted fluidized beds are widely used for particle coating because of its excellent mixing rates and favorable heat and mass transfer characteristics. The combination of Computational Fluid Dynamics (CFD) and the Discrete Element Method…

A combination of computational fluid dynamics (CFD), discrete element method (DEM), and discrete droplet method (DDM), i.e., a CFD-DEM-DDM model, was developed to simulate coating of pellets in a Wurster coater. The model equations were…

In pharmaceutical industry, a deep understanding on the physical properties of drug substance and excipients is critical for the quality control of solid dose drug product. The purpose of this work is to develop a quantitative…

In the production process of pharmaceutical pellets with a narrow size distribution and a high sphericity, a combined extrusion-spheronization technique is frequently used. The rounding of the wet cylindrical extrudates in the spheronizer…

Coating of particles is a widely used technique in order to obtain the desired surface modification of the final product, e.g., specific color or taste. Especially in the pharmaceutical industry, rotor granulators are used to produce round,…

Seeded granulation is one of the recently adopted wet granulation techniques. The seeded granules consist of high-density core nuclei and low-density particles layered on the outside. It depends on various process and formulation factors.…

Tablets can be manufactured using a rotary tablet press, which consists of a feed frame followed by the compression and compaction of the powder and subsequent ejection of the tablets. From Quality by Design (QbD) perspectives the feed…

Spouted beds are commonly simulated through the Computational Fluid Dynamics – Discrete Element Method approach. The choice of the drag model is still a matter of debate, as they feature peculiar operative conditions. In this work, we…

A full discharge process of a twin-screw feeder has been simulated with DEM (discrete element method). The result files are available at the Mendeley Data repository (https://doi.org/10.17632/d76rzzd8r7.1) and contain the following…

A novel ultrasonic instrumentation was successfully implemented in a compaction simulator. A through-transmission set-up was realised with longitudinal and transverse transducers being alternately positioned inside Euro-D-modified punches.…