Elucidating the impact of excipient variability on oral product performance in a biopharmaceutical perspective would be beneficial and allow excipient implementation on Quality by Design (QbD) approaches. The current study investigated the…

This study focuses on the impact of initial particle size on the tabletability and the deformation behaviour (i.e. plasticity) of granules produced by twin-screw melt granulation (TSMG). As model substances, three different grades of…

In recent times, a large number of studies concerning the improvement of the dissolution rate of poorly water-soluble drugs are focused on the application of various porous materials as the drug carriers. These materials have attracted the…

Many drugs belong to BCS class-2 having poor solubility in water requires enhancement in solubility and dissolution rate for increasing its oral bioavailability; however, in many cases, immediate onset of action is required than…

Liposomes, due to their mimetic cellular composition, are gaining great attention as release systems for lipophilic and hydrophilic molecules. However, liposomes can present a high tendency to degrade and aggregate into biological fluids…

1. Trouble finding a soluble DC filler/binder with pleasant taste and mouthfeel for non-GMO, lactose free formulations? TRY EMDEX® - REQUEST A SAMPLE EMDEX® is a directly compressible, water-soluble tablet binder and filler. Its…

Ubrelvy™ December 2019 and Koselugro™ April 2020 are the most recent FDA approval of drug using Vitamin E TPGS in the formulation. TPGS properties: Emulsifier - solubilizer of poorly soluble drugs - absorption enhancer - PgP inhibitor -…

Preparation of pharmaceutical nanosuspensions is a popular technique to increase the dissolution velocity of poorly water-soluble drugs. Subsequent drying into a compaction-ready powder or granule is a critical process due to possible…

Oral application of drugs is not only the most common way for systemic drug application, it is also patient’s route of choice. Oral formulations are – compared to injections or infusions – convenient and painless. As they do not require…