Multiple-unit dosage forms prepared by compacting pellets offer important manufacturing and compliance advantages over pellet-filled capsules. However, compaction may negatively affect the release control mechanism of pellets, and subunits…

The discussion about the excipient titanium dioxide in the European food industry is already several years old. TiO2 was banned from food products in the EU and other countries since 2022 as being maybe carcinogenic . This even had…

In this study, Enzalutamide (ENZ) loaded Poly Lactic-co-Glycolic Acid (PLGA) nanoparticles coated with polysarcosine and d-α-Tocopheryl polyethylene glycol 1000 succinate (TPGS) were prepared using a three-step modified nanoprecipitation…

The pharmaceutical industry is paying more and more attention to hot-melt extrusion (HME), but this technology's promise for creating solid self-emulsifying drug delivery systems (S-SMEDDS) has not yet been fully realized. The numerous…

Abstract The influences of the punch face design on multi-unit pellet system (MUPS) tablets were investigated. Drug-loaded pellets coated with sustained release polymer based on ethylcellulose or acrylic were compacted into MUPS tablets.…

After assessing the various routes of drug administration, oral delivery stands out as the safest and, as a result, the most universally accepted among patients. Single-unit dosage forms, including tablets followed by capsules, have been…

Abstract Cerebral ischemia represents a particular condition among neurological diseases due to its high frequency, high associated mortality, and the permanent disability in patients that survive it. Numerous studies in animal models have…

“Sticking” during tablet manufacture is the term used to describe the accumulation of adhered tablet material on the punch over the course of several compaction cycles. The occurrence of sticking can affect tablet weight, image, and…

Drug repurposing is promising strategy with niclosamide showing encouraging results against breast cancer. However, niclosamide hydrophobicity limits its oral bioavailability and minimizes its anti-cancer activity. Nano-structured lipid…

The widely used vitamin-E based amphiphilic material, tocopheryl polyethylene glycol succinate (TPGS) is further improvised as redox-sensitive thiolated TPGS (TPGS-SH), which has been developed by attaching 4-aminothiophenol. Further, TPGS…