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Development of a stability indicating high-performance liquid chromatography method for…

Apr 26, 2024

Abstract This study presents a stability indicating high-performance liquid chromatography HPLC method for the determination of cenobamate (CNB) in presence of its main impurity (CNB H-impurity) and degradation products. The…

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Development and application of control concepts for twin-screw wet granulation in the ConsiGma-25:…

Apr 26, 2024

Abstract Traditional operation modes, such as running the production processes at constant process settings or within a narrow design space, do not fully exploit the advantages of continuous pharmaceutical manufacturing. Integrating…

Sorbitol as Pharmaceutical Excipient

Apr 25, 2024

Sorbitol, a polyol also known as glucitol, plays a significant role in the pharmaceutical industry as a versatile excipient and active pharmaceutical ingredient (API). This sugar alcohol is widely utilized for its unique properties, serving…

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Advances in Nanocarrier Systems for Overcoming Formulation Challenges of Curcumin: Current Insights

Apr 25, 2024

Abstract Curcumin, an organic phenolic molecule that is extracted from the rhizomes of Curcuma longa Linn, has undergone extensive evaluation for its diverse biological activities in both animals and humans. Despite its favorable…

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Beyond Tableting Lubrication – PRUV® by JRS Pharma

Apr 25, 2024

PRUV® by JRS Pharma is a tablet lubricant designed for formulations in which other lubricants lead to formulation and/or manufacturing challenges. As opposed to the frequently used lubricant, magnesium stearate, PRUV® offers the following…

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Polymeric microspheres redefining the landscape of colon-targeted delivery: A contemporary update

Apr 25, 2024

Abstract During recent times, the delivery of the medications to the colon has seen more interest by the researchers, as it proved to be providing both options for treating local colon-related conditions and a route for systemic delivery…

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Effects of semaglutide-loaded lipid nanocapsules on metabolic dysfunction-associated steatotic liver…

Apr 24, 2024

Abstract Metabolic dysfunction-associated steatotic liver disease (MASLD) is a highly prevalent chronic liver disease that can progress to end-stage conditions with life-threatening complications, but no pharmacologic therapy has been…

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Preparation, Characterization, and Evaluation of a Novel Co-Processed Excipient as a Directly…

Apr 23, 2024

Direct compression stands out as the preferred method for tablet preparation, with co-processing being extensively explored and commercially employed for creating directly compressible vehicles. This study aims to synthesize and…

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Benefits of an Optimal Tabletability DC Mannitol on Compression Setting Parameters

Apr 22, 2024

This case study was presented at the 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 18 - 21 March 2024, Vienna, Austria: INTRODUCTION An increasing number of APIs present stability challenges and…

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Amorphous – state Characterization and Dissolution Behaviour of Efavirenz – Tocopheryl…

Apr 22, 2024

ABSTRACT The aim of the present investigation was to enhance the aqueous solubility and dissolution rate of a poorly soluble drug, efavirenz, by preparation of solid dispersions with tocopheryl polyethylene glycol succinate (TPGS)-1000, a…

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