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Storage stability of inhalable phage powders containing lactose at ambient conditions

Feb 6, 2019

The aim of this study was to evaluate the storage stability of inhalable phage powders containing lactose and leucine as excipient. As an FDA-approved excipient for inhalation, lactose is preferred over other sugars. PEV phages active…

Lipids

Lipid Excipients for Cannabinoid Drug Products

Feb 6, 2019

The introduction of the cannabis plant into Western medicine dates to the 19th century when the plant was first used as an additive to patented medicines. The development of cannabis based therapies in the modern sense however came to a…

3D Printing

Abuse Deterrent Immediate Release Egg-Shaped Tablet (Egglets) Using 3D Printing Technology

Jan 20, 2019

Opioid abuse is a growing problem and has become a national health crisis over the past decade in the USA. Oral ingestion, snorting, and injection are the most commonly employed routes of abuse for an immediate release product. To…

Acrylic Polymers

Design, formulation and manufacture of film-coated drug products

Jan 17, 2019

Film coating is a common step in tablet manufacture that can be used to improve product appearance, organoleptic properties, or to facilitate swallowing. Functional film coats can also be used as a part of the product’s stabilisation…

Solubilizer

Integrating the drug, disulfiram into the vitamin E-TPGS-modified PEGylated nanostructured lipid…

Jan 8, 2019

The ‘repurposed drug,’ disulfiram (DSF), is an inexpensive FDA-approved anti-alcoholism drug with multi-target anti-cancer effect. However, the use of DSF in clinical settings remains limited due to its high instability in blood. In the…

Methods of Analysis Used in Taste Masking

Jan 3, 2019

Many methods have been explored over the years to characterize and quantify the sensory attributes of APIs and drug products – taste, aroma, trigeminal irritancy and texture. These include in-vitro techniques and sensory analysis by trained…

Binder

Evaluation of in-line particle measurement with an SFT-probe as monitoring tool for process…

Dec 14, 2018

The Process Analytical Technology (PAT) initiative published by the Food and Drug administration (FDA) describes PAT systems as important tools to optimize pharmaceutical processes in order to ensure the final product quality. Real-time…

Inorganic Chemicals

To use Talc or not to use Talc: Should this even be a Question?

Nov 30, 2018

Magnesium silicate (MgSiO3) when hydrated is most commonly known as “Talc”. In the pharmaceutical industry, talc is used primarily as a glidant to improve powder flow in tablet compression. Of course, talc is also used by the personal care…

Solids

Solid Oral Dose Process Validation

Nov 23, 2018

Currently there are no process validation (PV) textbooks addressing the lifecycle concepts (Stage 1, 2, 3). Recent regulatory guidance's such as US FDA, EMEA, WHO, PIC/S have adopted the ICH lifecycle approach. The concepts are now…

News

The Taste of 101 API’s summarized

Nov 22, 2018

It is widely recognized that many Active Pharmaceutical Ingredients (APIs) are bitter, some extremely so. But bitterness is not the only challenge in creating palatable, patient-accepted drug products. If not bitter, what are other common…

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