The aim of this study was to determine the effect of varying excipient content on the formation and physical properties of 3D printed tablets. Fifteen different excipient preparations were formed into tablets with radii of 5 mm and…

The use of non-aqueous cellulose-based formulations for extrusion-spheronisation (E-S) is investigated. A 10 wt% hydroxypropyl cellulose/isopropyl alcohol solution (HPC/IPA) was identified as a suitable sticky liquid binder for preparing…

During formulation development, there are cases when, serendipitously, drug or excipients play a different role than intended one or a dual role. One of the examples of a non-traditional role is of a drug acting as a plasticizer.…

The aim of this study was to prepare and evaluate Ibuprofen (IBU) solid dispersion tablets with improved dissolution and less sticking using Porous Calcium Silicate (PCS). Solid dispersion granules were prepared using water-based solid…

The aim of this work was to evaluate gellan gum as binder in pellet formulations, with theophylline as the model drug, in comparison with polyvinylpyrrolidone (PVP). A full 32 factorial design was realized, with binder and dilu- ent factors…

Pharmaceutical excipients are an important part of any formulation and still we do not know enough about them. We therefore aim to improve the general knowledge on pharmaceutical excipients and have launched "Excipient Basics" on…

Drum granulation can be used to form biochar granules that could reduce dust hazards during biochar application to soils. An investigation of the effect of operational parameters using three biochar feedstock was conducted to identify the…

Three-dimensional printing (3DP) is a rapidly growing additive manufacturing process and it is predicted that the technology will transform the production of goods across numerous fields. In the pharmaceutical sector, 3DP has been used to…

Granulation, the process of particle enlargement by agglomeration technique, is one of the most significant unit operations in the production of pharmaceutical dosage forms, mostly tablets and capsules. Granulation process transforms fine…

Abstract Granulation is a size-enlargement process by which small particles are bonded, by means of various techniques, in coherent and stable masses (granules), in which the original particles are still identifiable. In wet granulation…