Introduction: Amorphous formulation technologies to improve oral absorption of poorly soluble active pharmaceutical ingredients (APIs) have become increasingly prevalent. Currently, polymer based amorphous formulations manufactured by spray…

Amorphization serves as a strategy for the improvement of poor dissolution characteristics of many drug compounds. However, in many formulations the content of polymeric stabilizer is high, which is undesirable from the perspective of…

The present works contributes with a rheological characterization of the most commonly used polymers and solvents to formulate amorphous solid dispersions by means of spray drying process: copovidone, hydroxypropyl methylcellulose (HPMC),…

Solid dispersion is the preferred technology to prepare efficacious forms of BCS class-II/IV APIs. To prepare solid dispersions, there exist a wide variety of polymeric carriers with interesting physicochemical and thermochemical…

PLGA-PEG-PLGA are copolymers, able to form temperature-dependent hydrogels or sol dispersions at selective conditions. A general overview about the rheological characterization of their aqueous dispersions, focusing how the structural…

PURPOSE Poor aqueous solubility is a significant issue in the current pharmaceutical industry with approximately 90% of new chemical entities in the development pipeline characterised as poorly watersoluble. Amongst various means to…

Physical instability arguably is the major challenge in using neat amorphous active pharmaceutical ingredients in everyday tablets and capsules. The conversion of an amorphous form to the crystalline state either during storage or drug…

Solid dispersions – a great way to increase the solubility and bioavailability of your drug In a solid dispersion the drug is dispersed in a carrier with the system appearing to be in a solid state. Target is an increase in solubility and…

Adequate aqueous solubility of active pharmaceutical ingredients (APIs) is a crucial factor for therapeutic effectiveness. Today, more than fifty percent of the new potential APIs are exhibiting poor aqueous solubility/dissolution rate,…