The aim of this article was to design a self-emulsifying drug delivery system (SEDDS) of loaded cepharanthine (CEP) to improve the oral bioavailability in rats. Based on the solubility determination and pseudo-ternary phase diagram,…

Respiratory viral infections are major cause of highly mortal pandemics. They are impacting socioeconomic development and healthcare system globally. These emerging deadly respiratory viruses develop newer survival strategies to live inside…

SARS-CoV-2, a RNA-virus within the Corona family, has affected mankind all over the world and was therefore declared as pandemic (COVID 19). Since first appearance of this infection, global science and technology has reacted incredibly…

The current world health threat posed by the novel coronavirus disease of 2019 (COVID-19) calls for the urgent development of effective therapeutic options. COVID-19 needs daunting routes such as nano-antivirals. Hence, the role of…

Severe Acute Respiratory Syndrome associated coronavirus 2 (SARS-CoV-2) has caused a global public health crisis with high rates of infection and mortality. Treatment and prevention approaches include vaccine development, the design of…

mRNA vaccines have become a versatile technology for the prevention of infectious diseases and the treatment of cancers. In the vaccination process, mRNA formulation and delivery strategies facilitate effective expression and presentation…

In this work, we have developed and tested in vivo a dry powder form of niclosamide made by thin-film freezing (TFF) and administered it by inhalation to rats and hamsters. The niclosamide dry powder, suitable for inhalation, is being…

What's in a vaccine? With the emergence of COVID-19, the crucial role that vaccines play in protecting our health has come into sharp focus. During this pandemic hope comes in the form of a vaccine and immunologists around the world are…

mRNA vaccines represent a promising alternative to conventional vaccine approaches because of their high potency, capacity for rapid development and potential for low-cost manufacture and safe administration. However, their application has…

Covid-19 vaccination has been a big topic and we were curious on the role of excipients in such formulations. Not surprisingly both Pfizer-BioNTech and Moderna (source FDA) have quite similar compositions: Active Ingredient, Lipids and a…