Treatment of posterior uveitis via topical route is desirable but cannot be achieved by conventional drug delivery strategies. Therefore, the aim of this study is to develop a topical nanomicellar formulation of an immunosuppressant drug,…

Preparing a suitable formulation for parenteral administration is already a difficult task; this, coupled with poor water-soluble new chemical entity (NCE), complicates this situation even further. There are several methodologies available…

What's in a vaccine? With the emergence of COVID-19, the crucial role that vaccines play in protecting our health has come into sharp focus. During this pandemic hope comes in the form of a vaccine and immunologists around the world are…

Amorphous solid dispersions (ASDs) have emerged as widespread formulations for drug delivery of poorly soluble active pharmaceutical ingredients (APIs). Predicting the API solubility with various carriers in the API–carrier mixture and the…

Vaginal films featuring the pH-dependent release of tenofovir (TFV) were developed for the prevention of sexual transmission of human immunodeficiency syndrome (HIV). Films based on hydroxypropyl methylcellulose and zein were prepared…

Review article by Mariana C. Castells, M.D., Ph.D., and Elizabeth J. Phillips, M.D. in The NEW ENGLAND JOURNAL of  MEDICINE  To date, the development of mRNA vaccines for the prevention of infection with the severe acute respiratory…

Oral drug therapy is generally provided in the form of solid oral dosage forms (SODF) that have to be swallowed and move throughout the oro-esophageal system. Previous studies have provided evidence that the oro-esophageal transit of SODF…

Oral drug administration provided as solid oral dosage forms (SODF) remains the major route of drug therapy in primary and secondary care. There is clear evidence for a growing number of clinically relevant swallowing issues (e.g.,…

Covid-19 vaccination has been a big topic and we were curious on the role of excipients in such formulations. Not surprisingly both Pfizer-BioNTech and Moderna (source FDA) have quite similar compositions: Active Ingredient, Lipids and a…