The spread of SARS-CoV-2 and ongoing COVID-19 pandemic underscores the need for new treatments. Here we report that cannabidiol (CBD) inhibits infection of SARS-CoV-2 in cells and mice. CBD and its metabolite 7-OH-CBD, but not THC or other…

As a complement to vaccines, small-molecule therapeutic agents are needed to treat or prevent infections by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and its variants, which cause COVID-19. Affinity selection–mass…

Cannabis was banned almost everywhere on earth for nearly eight decades. But legalisation in many parts of the world triggered a boom in demand. In the meantime, the “green rush” has become a popular term, based on the “gold rush”. Cannabis…

Enhancing cannabinoids’ therapeutic efficacy In our previous technical note, we reported on the encapsulation of CBD vs THC (1) into lipid-based nanoparticles. The work here-in continues on that theme in terms of studying the differences…

This work describes the application of the liquisolid technique to enhance cannabinoid dissolution from Cannabis sativa L. (CS) compacts. The effects of five vehicles, namely, volatile (ethanol) and nonvolatile (caprylocaproyl…

The number of lipophilic drug candidates in pharmaceutical discovery pipelines has increased in recent years. These drugs often possess physicochemical properties that result in poor oral bioavailability, and their clinical potential may be…

Data-enriched edible pharmaceuticals (DEEP) is an approach to obtain personalized medicine, in terms of flexible and precise drug doses, while at the same time containing data, embedded in quick response (QR) codes at a single dosage unit…

Medicinal Cannabinoids There are currently more than 150 cannabinoid-based products under development in the world. The first US FDA approved product Epidiolex®, isolated from the cannabis plant and indicated for severe forms of epilepsy…

A microporous material made of cyclodextrin units covalently immobilized into a silica network has found an innovative bioanalytical application in the sample clean-up and simultaneous isolation of three synthetic cannabinoids (ADB-CHMICA,…